PUBLICATIONS
Legend
* Authors contributed equally
Underlined authors are trainees from the Bruin Lab
2024
van Allen K, Gang N, Hoyeck MP, Perera I, Zhang D, Atlas E, Lynn FC, Bruin JE. Characterizing the effects of Dechlorane Plus on β-cells: a comparative study across models and species. Islets, 16:1, 2361996 (2024).
Grieco-St-Pierre L, Bruin JE. Type 2 diabetes is not one-size-fits-all: Subtypes affect complications and treatment options”, The Conversation Canada, April 18 (2024).
Ching AME, Hoyeck MP, Basu L, Merhi R, van Zyl E, Crawley AM, Bruin JE. CYP1A1/1A2 enzymes mediate glucose homeostasis and insulin secretion in mice in a sex-specific manner. BioRxiv (2024).
Hoyeck MP, Ching AME, Basu L, van Allen K, Palaniyandi J, Perera I, Poleo-Giorgani E, Hanson AA, Ghorbani P, Fullerton MD, Bruin JE. The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice. Molecular Metabolism. Feb 2;81:101893 (2024).
2023
Palaniyandi J, Bruin JE, Kumarathasan P, MacPherson S, Borghese MM, Ashley-Martin J. Prenatal exposure to perfluoroalkyl substances and inflammatory biomarker concentrations. Environmental Epidemiology. Jul 25;7(4):e262 (2023).
Hoyeck MP, Merhi RC, Tulloch C, McCormick K, Mohammed Abu Hossain S, Hanson AA, Bruin JE. Fetal and neonatal dioxin exposure causes sex-specific metabolic alterations in mice.Toxicological Sciences. Jun 28;194(1):70-83 (2023).
2022
Basu L, Bruin JE. Why South Asians are at increased risk for diabetes: A complex interplay of genetics, diet and history. The Conversation. Published November 14 (2022).
Hoyeck M*, Matteo G*, MacFarlane EM, Perera I, Bruin JE. Persistent organic pollutants and β-cell toxicity: a comprehensive review. American Journal of Physiology - Endocrinology & Metabolism. May 1;322(5):E383-E413 (2022).
Gang N, Van Allen K, Villeneuve P, MacDonald H, Bruin JE. Sex-specific associations between type 2 diabetes incidence and exposure to dioxin and dioxin-like pollutants: a meta-analysis. Frontiers in Toxicology. Vol 3, Article 685840 (2022).
2021
Matteo G*, Hoyeck M*, Blair H, Zebarth J, Rick KRC, Williams A, Gagné R, Buick JK, Yauk CL, Bruin JE. Prolonged low-dose dioxin exposure impairs metabolic adaptability to high-fat diet feeding in female but not male mice. Endocrinology, 162(6):1-18 (2021).
MacFarlane EM, Bruin JE. Human pluripotent stem cells: a unique tool for toxicity testing in pancreatic progenitor and endocrine cells. Frontiers in Endocrinology. Jan 19;11:604998 (2021).
2020
Hoyeck M, Merhi R, Blair HL, Spencer DC, Payant MA, Alfonso DI, Zhang M, Matteo G, Chee MJ, Bruin JE. Female mice exposed to low doses of dioxin during pregnancy and lactation have increased susceptibility to diet-induced obesity and diabetes. Molecular Metabolism. Dec;42:101104 (2020)
Ibrahim M, MacFarlane EM, Matteo G, Hoyeck MP, Rick KRC, Farokhi S, Copley CM, O'Dwyer S, Bruin JE. Functional cytochrome P450 1A enzymes are induced in mouse and human islets following pollutant exposure. Diabetologia. 63(1):162-178 (2020).
Hoyeck MP, Blair H, Ibrahim M, Solanki S, Elsawy M, Prakash A, Rick KRC, Matteo G, O'Dwyer S, Bruin JE. Long-term metabolic consequences of acute dioxin exposure differ between male and female mice. Scientific Reports. 10(1):1448 (2020).