The Bruin Laboratory | Carleton University, Ottawa | (613) 520-2600 x3656

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© 2017 by Bronwyn E. Rowland.

PUBLICATIONS

Legend
* Authors contributed equally

2016

Bruin JE*, Saber N*, Fox JK, Mojibian M, Arora P, Rezania A, Kieffer TJ. Hypothyroidism impairs human stem cell-derived pancreatic progenitor cell maturation in mice. Diabetes. 65(5):1297-1309 (2016).

[Full Text] [Commentary Article]

Szabat M, Page MM, Panzhinskiy E, Skovsø S, Mojibian M, Fernandez-Tajes J, Bruin JE, Bround MJ, Lee JTC, Xu EE, Taghizadeh F, O’Dwyer S, van de Bunt M, Moon KM, Sinha S, Han J, Fan Y, Lynn FC, Trucco M, Borchers CH, Foster LJ, Nislow C, Kieffer TJ, Johnson JD. Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β-Cell Proliferation. Cell Metabolism.  23(1):179-93 (2016).

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2015

Bruin JE, Rezania A, Kieffer TJ. Replacing and safeguarding pancreatic beta cells for diabetes. Science Translational Medicine. Dec 2; 7(316):316ps23 (2015).

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Bruin JE, Fox JK, Asadi A, Rezania A, Kieffer TJ. Accelerated maturation of human stem cell-derived pancreatic progenitor cells into insulin-secreting cells in immunodeficient rats relative to mice. Stem Cell Reports, 5: 1081-1096 (2015).

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Quiskamp N, Bruin JE, Kieffer TJ. Differentiation of human pluripotent stem cells into beta cells: potential and challenges. Best Practice and Research Clinical Endocrinology and Metabolism. 29(6):833-47 (2015).

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Bruin JE, Saber N, Braun N, Fox JK, Mojibian M, Asadi A, Drohan C, O’Dwyer S, Rosman-Balzer DS, Swiss VA, Rezania A, Kieffer TJ. Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs. Stem Cell Reports. 4(4):605-620 (2015).

[Full Text] [Interviewed by Global TV] [Highlighted by Nature["Best of Stem Cell Reports, 2015-2016"]

 

Asadi A* , Bruin JE*,  Kieffer TJ. Characterization of antibodies to products of proinsulin processing using immunofluorescence staining of pancreas in multiple species. Journal of Histochemistry & Cytochemistry. 63(8):646-62 (2015). 

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2014

Rezania A, Bruin JE, Arora P, Rubin A, Batushansky I, Asadi A, O'Dwyer S, Quiskamp N, Mojibian M, Albrecht T, Yang YH, Johnson JD, Kieffer TJ. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nature Biotechnology. 32:1121-1133 (2014).

[Full Text] [Highlighted by Hanley N. in Nature Biotechnology]

 

Bruin JE,  Erener S, Vela J, Hu X, Kurata HT, Johnson JD, Lynn FC, Piret JM, Rezania A, Kieffer TJ. Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells. Stem Cell Research. 12(1):194-208 (2014).

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2013

Bruin JE*, Rezania A*, Xu J, Narayan K, Fox JK, O’Neil JJ, Kieffer TJ. Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macro-encapsulation devices following transplant into mice. Diabetologia. 56(9):1987-98 (2013).

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Rezania A*,  Bruin JE*, Xu J*, Narayan K, Fox JK, O’Neil JJ, Kieffer TJ. Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo. Stem Cells. 31(11):2432-42 (2013).  *Authors contributed equally.

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Tuduri E,  Bruin JE, Denroche HC, Fox JK, Johnson JD, Kieffer TJ. Impaired Ca2+ signaling in beta cells lacking leptin receptors by Cre-loxP recombination. PLoS One. 8(8):e71075 (2013).

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Denroche HC, Quong WL,  Bruin JE, Tuduri E, Asadi A, Glavas MM, Fox JK, Kieffer TJ. Leptin administration enhances islet transplant performance in diabetic mice. Diabetes. 62(8):2738-46 (2013).

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Mojibian M, Harder B, Hurlburt A,  Bruin JE, Asadi A, Kieffer TJ. Implanted islets in the anterior chamber of the eye are prone to autoimmune attack in a mouse model of diabetes. Diabetologia. 56(10):2213-21 (2013).

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2012

Rezania A* , Bruin JE*,  Riedel MJ, Mojibian M, Asadi A, Xu J, Gauvin R, Narayan K, Karanu F, O’Neil JJ, Ao Z, Warnock GL, Kieffer TJ. Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets in diabetic mice. Diabetes.  61(8):2016-29 (2012).

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Tuduri E, Bruin JE, Kieffer TJ. Restoring insulin production for type 1 diabetes. Journal of Diabetes. 4:319-331 (2012).

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Bruin JE,  Woynillowicz AK, Tarnopolsky MA, Hettinga BP, Gerstein HC, Holloway AC. Maternal antioxidants prevent beta cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure. Journal of Diabetes. 4(3):297-306 (2012).

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Bruin JE and Kieffer TJ. Differentiation of human embryonic stem cells into pancreatic endocrine cells. Hayat, MA (ed). Stem Cells and Cancer Stem Cells: Therapeutic Applications in Disease and Injury. Springer. Vol 8, Chapter 18, p 192-206 (2012).

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2011

Lagunov A, Anzar M, Sadeu JC, Khan MIR, Bruin JE, Woynillowicz AK, Buhr M, Holloway AC, Foster WG. Effect of in utero  and lactational nicotine exposure on the male reproductive tract in peripubertal and adult rats. Reproductive Toxicology.  31(4):418-423 (2011).

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2010

Bruin JE, Gerstein HC, Holloway AC. Long-term consequences of fetal and neonatal nicotine exposure: a critical review. Toxicological Sciences. 116(2):364-74 (2010).

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Kellenberger L,  Bruin JE, Greenaway J, Solinger NE, Moorehead R, Holloway AC, Petrik J. The role of dysregulated glucose metabolism in epithelial ovarian cancer. Journal of Oncology. 2010:514310 (2010).

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Bruin JE, Petrik JJ, Hyslop J, Tarnopolsky MA, Raha S, Gerstein HC, Holloway AC. Rosiglitazone improves pancreatic mitochondrial function in an animal model of dysglycemia: Role of the insulin-like growth factor axis. Endocrine. 37(2) 303-311 (2010).

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2008

Bruin JE, Petre MA, Raha S, Morrison KM, Gerstein HC, Holloway AC. Fetal and neonatal nicotine exposure in Wistar rats causes a progression of pancreatic mitochondrial alterations and leads to beta cell dysfunction. PLoS ONE. 3(10):e3371 (2008).

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Bruin JE, Petre MA, Lehman MA, Raha S, Gerstein HC, Morrison KM and Holloway AC. Maternal nicotine exposure increases oxidative stress in the offspring. Free Radical Biology and Medicine. 44(11):1919-25 (2008).

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Holloway AC, Petrik JJ,  Bruin JE, Gerstein HC. Rosiglitazone prevents diabetes by increasing beta-cell mass in an animal model of type 2 diabetes characterized by reduced beta-cell mass at birth. Diabetes Obesity and Metabolism. 10(9):763-71 (2008).

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Bruin JE, Gerstein HC, Morrison KM and Holloway AC. Increased pancreatic beta cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria. Toxicological Sciences. 103(2):362-70 (2008).

[Full Text] [Highlighted by Borowitz JL and Isom GE in Toxicological Sciences]

2007

Bruin JE, Kellenberger LD, Gerstein HC, Morrison KM, Holloway AC. Fetal and neonatal nicotine exposure and postnatal glucose homeostasis: Identifying critical windows of exposure. Journal of Endocrinology. 194(1):171-8 (2007).

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